Based on the core technology of the next generation Internet IPv6, which has the characteristics of large enough address space, higher security, better service quality and supporting mobile terminal equipment, the information development of universities is gradually promoting the IPv6 network deployment and IPv6 network application of information system. However, in the process of promoting IPv6 network deployment and access of application systems in universities, there are still some problems that some un‐ derlying network devices do not support IPv6 protocol, and security devices cannot achieve comprehensive control. In order not to change the current school network architecture, without affecting the current IPv4 network access, this paper puts forward the imple‐ mentation of IPv6 network deployment and access for college Web application system based on the intelligent DNS and reverse proxy. This technology has the characteristics of simple principle, strong stability, high security and easy maintenance. Through link‐ age deployment, IPv6 network access and IPv4 access security reinforcement of the school application system are realized, which provides reference practice for the deployment of IPv6 network application.