Since the implementation of innovation and entrepreneurship education, students' innovation and entrepreneurship ability has been significantly improved. With the rapid development of information technology, a number of technical innovation experts and advanced entrepreneurship models have emerged in the software major of higher vocational colleges, but there are still some problems in innovation and entrepreneurship education that need to be further solved. The full implementation of the "1 + X" certificate system provides a theoretical basis for teaching reform. Exploring the integration of the advanced concept of the "1 + X" certificate system into the innovation and entrepreneurship education of software major can bring new breakthroughs to the cultivation of information technology talents.