Natural interaction and multi-sensory experience make virtual reality animation enter an unprecedented stage of art perception. Its interactive methods and strategies, and the sensory experience of interactive feedback need to be theoretically sorted out and found new laws. This paper mainly analyzes the application of "interaction perception" mode principle, natural interaction mode and interactive feedback in virtual reality animation, demonstrates that natural interaction mode and multi-sensory experience provide a new creation form for animation creation, and makes thinking on the interaction form and experience form of virtual reality animation in the future.