Against the backdrop of the development of new engineering disciplines, this paper addresses the problems existing in the traditional teaching of Data Mining and proposes a teaching reform path based on school-enterprise cooperation. In the reform, a three-dimensional teaching objective oriented towards industrial demands is reconstructed, an online-offline blended teaching mode is integrated, real enterprise projects are introduced to build a practical challenge mechanism, and a comprehensive evaluation system involving multiple subjects such as university teachers, enterprise teachers, and students is established. It promotes the deep integration of course teaching with the cutting-edge technologies and business scenarios in the industry, thereby enhancing students' engineering practice ability, innovation awareness, and professional qualities.