Under the promotion of the information and innovation strategy, in order to cultivate highly skilled talents that meet with the needs of the Internet of Things industry, this article takes the courses of C Language Programming and Microcontroller Technology and Application in the Internet of Things Application Technology major of vocational colleges as the research object, and uses literature research, case analysis, and practical verification methods to explore the integrated teaching path of the two courses. The research aims to form an integrated teaching system by integrating teaching content, innovating teaching methods, strengthening practical activities, building a teaching team, and constructing a teaching platform based on the Hi3861 chip. Practical case studies will be presented in conjunction with serial communication programming. The results show the significant improvement in students' comprehensive practical abilities, the increase in the number of awards in subject competitions, and enhanced interest in learning and recognition of domestic technology. Research shows that the integration of two courses in teaching can effectively connect knowledge systems, improve teaching quality, and provide practical references for the reform of relevant professional courses in vocational colleges under the background of information and innovation.