With the increasing integration of the new generation of information technology and education, education and teaching are facing the requirements of digital transformation. As a modern digital information technology, knowledge graph is a key technology in the digital construction of education, and plays an important role. This paper proposes a six-in-one teaching digitization path based on knowledge graph with "human, infrastructure, material, method, environment and evaluation", and puts forward corresponding implementation strategies from the aspects of transforming the roles of teachers and students, improving digital infrastructure, enriching teaching resources, innovating teaching methods and means, optimizing teaching environment, and constructing diversified teaching evaluation system, etc. The implementation measures and effects are illustrated with the cases of specific courses. It provides reference for promoting digitalization of teaching.