The online teaching practice of Mobile Communication course is explored during the epidemic period in this paper. Under the guidance of teachers, adopting the heuristic, discussion and question-driven teaching methods of student-centered and making use of the advantage of online learning through teaching design, interactive communication channels, learning effect evaluation and other ways, we can improve teaching, stimulate students' interest in learning, and cultivate students' autonomous learning ability, so as to achieve the substantial equivalence between online learning and offline classroom teaching quality proposed by the Ministry of Education. The practical exploration provides reference for the effective development of online and offline hybrid teaching in the post epidemic period.