In view of the complexity, multi-constraint and multi-objective characteristics of production scheduling in process indus- try, an enhanced collaborative optimization algorithm (NCO) is proposed, which is applied to solve multi-objective optimization problems, and a multi-objective collaborative optimization method (MONCO) based on NCO is proposed. The simulation results show that MONCO algorithm can not only optimize the effect, but also reduce the number of iterations and improve the computa- tional efficiency