Taking the innovation and entrepreneurship system reform strategy of medical information engineering specialty in the era of "Internet+" as the research purpose, firstly, the necessity of innovation and entrepreneurship system reform of medical information engineering specialty is expounded. Secondly, the problems encountered in the reform process of medical information engineering specialty innovation and entrepreneurship system are analyzed. Finally, the reform strategy is put forward aiming at the existing problems and facing the "Internet +". With the development of the times, the medical information engineering specialty can keep pace with the development of the times, to cultivate innovative and entrepreneurship talents and provide a perfect platform for innovation and entrepreneurship.