Drug safety is directly related to the life and health of patients. The state has issued stringent crackdown measures, but the problem of counterfeit drugs is still emerging. One of the main reasons is the lack of appropriate technical means for anti-counterfeiting management of drugs. Based on the trusted two-dimensional code, combined with the actual circulation process of drugs, this paper provides a safe and credible anti-counterfeiting system for drugs, realizing the legitimacy certification of manufacturers, distributors and drugs, and solving the problems of anti-counterfeiting of drugs.