The development of higher vocational education is closely related to the local economy. The optimization of professional setting in vocational colleges directly affects the structure of talents and promotes the development of economy. The development of economy also affects the professional setting of higher vocational colleges. Therefore, the matching of the professional setting of vocational colleges and local economic development is particularly important. Taking the computer specialty of the vocational colleges in Henan Province as an example, this paper analyzes the professional allocation of vocational colleges in Henan Province, and puts forward the optimization plan to realize the sustainable development of higher vocational colleges and the economy.