Vocational college campus network is a complex network. It faces with the increasingly prominent risk of information security while supporting the campus business operation and development. It becomes one of the urgent problems of school management. This paper analyzes the characteristics and information security situation of campus network in higher vocational colleges, proposes to build the information security protection system with "hierarchical protection, regional isolation, highlighted core, defense in depth. It combines with the practice to discuss and analyze, providing necessary reference for campus network information security and protection.