Flipped classroom generates with the development of modern information communication, especially the development of Internet technology, which is a new teaching mode. It changes the traditional teaching mode, changes the role of teachers and students, so that students really participate in the whole process of learning. It effectively improves the efficiency of classroom teaching. This paper studies on the application of flipped classroom teaching mode in flash animation design and production. Results show that flipped classroom teaching mode can be carried out before class, in class and after class. It doesn’t subject to geographical restrictions. It greatly improves the efficiency of classroom teaching and students' learning enthusiasm, and cultivates students' ability of thinking independently.