In recent years, with the rapid development of science and technology, the domestic industry has achieved rapid development, and the smart campus is gradually forming a new technology system under this environment. The construction process of smart campus will inevitably promote the rapid growth of database. In view of this, this paper mainly analyzes the security risks in the current big database of domestic smart campus. Taking the system architecture design as the starting point of database design, it draws up a reasonable, safe and scientific safety protection scheme for big database of smart campus, hoping to enhance the safety of database information and the running.