For predicting complex economic data, selecting suitable prediction model is the key to improve the prediction accuracy. This paper uses the combination of grey model and regression model to predict the high technology industry output in Guizhou. Taking the advantages of this combination model can improve the linear regression model by considering the exponential growth and improve the grey model by considering the linear factor, so as to achieve the goal of improving the prediction accuracy. And the computer numerical simulation results show the effectiveness of the combination forecasting model.