This paper designs the management system of reproductive medicine center, realizing the information management for all links including reservation, registration, reception, diagnosis, treatment, assisted reproduction operation, embryo cryopreservation, post-operation appointment, etc. It uses Client/Server as architecture, SQL SERVER as backend database, and Visual Basic 6.0 and Crystal Report 7.0 as the front platform developing tools, to develop different system modules. The system achieves good results in Reproductive Medicine Center of grade III-A hospitals. It can implement E-transactions, orderly diagnosis, standardized management and scientific policy-making.