With the advent of the era of informatization and digitization, science and technology develop constantly. And the communication network is widely used in people's daily life. In addition, the mobile communication promotes the development of computer technology, while network technology promotes the development of information technology. Cloud computing promotes the development of mobile communication network. In this paper, Cloud computing is mainly introduced. Based on the current status of mobile communication network optimization, the cloud computing is creatively combined with mobile communication network optimization.