The software talents cultivated by Chinese universities can not satisfy the practical post requirement of enterprise. In this paper, we take the software engineering specialty of Hefei University as an example to introduce the implementation idea of teaching reform based on modularization. Then, we discuss some practical measures of reform which includes specialty ability standard construction, modularized curriculum system construction, teaching method reform and autonomous expansive learning, etc. Finally, we indicate that the modularization-based teaching reform can efficiently cultivate applied talents with strong application innovation ability and post adaptability in software engineering.