The new technology and new concept in the era of digital intelligence have profoundly changed the way of operation, organization, production and decision-making in all walks of life. Under the impact of Big Data and Artificial Intelligence, the employment position has higher requirements for the computer skills and literacy of applied talents. The course of Computer Public Basic aims at cultivating students' computational thinking, computer technology and literacy, which plays an important role in improving the vocational skills of applied talents. Take Daqing Normal University, an application-oriented undergraduate university with characteristics in Heilongjiang Province, for example, this paper introduces the reform and practice of the education model of Computer Public Basic. On the basis of analyzing the computer ability required for application-oriented talents in the new era, this paper introduces the reform and practice path from four aspects: hierarchical curriculum system, mixed teaching mode, experimental teaching reform and innovation and entrepreneurship ability training.