For dealing with the noise image processing in the real scene, this paper proposes a denoising algorithm based on convolu- tional neural network according to the noise model which closer to the real scene. The algorithm uses multiple convolution layers in the convolutional neural network to learn the data characteristics of the noise image in the real scene, so as to continuously optimize its own parameters. The simulation results show that the denoising algorithm based on convolutional neural network has a good de- noising effect on the noise image in real scene, the denoised image is clearer, the visual effect is better, and the edge details in the im- age are well preserved.