Under the background of Education Informatization 2.0, information literacy is the necessary ability for the students in higher vocational colleges to adapt to the information society and lifelong learning. Aiming at the problem that the information literacy of the students in higher vocational colleges is on the low side generally, taking the course of engineering economics as an example, this paper builds a framework on top of the hybrid teaching model of SPOC based on improving the information literacy and then carries out practical research. Finally, the paper analyzes the teaching effect of applying the model. The results shows that the model fully plays the subject role of students in the process of education and teaching, realizes the improvement of information literacy, develops the students’comprehensive ability, so the mode is an effective teaching model to improve the quality of students.